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. 2017 Dec 21;11:1179069517748600. doi: 10.1177/1179069517748600

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© The Author(s) 2017

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 3. — Intrinsic desensitization within insect olfactory neurons. (A-C) Prolonged odorant exposure or (D-F) light activation reduces phosphorylation of Orco^S289 without altering Orco localization in the cilia. (A) ORNs activated by odorants. (B) Phospho-Orco^S289 immunoreactivity in the absence or presence of activating odorant. Odorants trigger the dephosphorylation of Orco^S289. (C) Anti-Orco serum reveals no change in total Orco localization with or without odorant exposure. (D) Red-shifted channelrhodopsin (ReaChR)³¹ expressed in the ORN allows activation of the ORNs without odorant. (E) Phospho-Orco^S289 immunoreactivity in flies expressing ReaChR in the olfactory neurons without and with red light exposure. Neuronal activation reduces the phospho-Orco^S289 signal. (F) Total Orco levels and localization do not change on light activation in the ORNs expressing ReaChR before or after red light exposure. Orco indicates odorant receptor coreceptor; ORN, olfactory receptor neuron.