Fig. 2.

Silencing of CCAT2 inhibits PDAC cell proliferation and invasion in vitro. a CCAT2 expression was compared between HPDE6-C7, a normal human pancreatic ductal epithelial cell line, and three PDAC cell lines, including PANC-1, SW1990 and PC-3. **P < 0.01; *P < 0.05. b CCAT2 expression in si-CCAT2-treated PANC-1 cells was compared to that in cells with no treatment (No-treat) or cells treated with scramble siRNA (Scramble). *P < 0.05 as compared with Scramble. c MTT assay detected fold change of cell growth rate in PANC-1 cells with no treatment, treated with Scramble siRNA or si-CCAT2 for 0, 24, 48, 72, and 96 h. *P < 0.05 as compared with Scramble. d Transwell assay evaluated cell invasion in si-CCAT2-treated and Scramble-treated PANC-1 cells. *P < 0.05. Representative images were shown on the left. From a to d, data shown were mean ± SEM of three independent biological repeats