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. 2017 Nov 26;10:170–186. doi: 10.1016/j.omtn.2017.11.011

Figure 2.

Figure 2

Knockdown of LINC00339 Inhibited VM Formation

(A) Relative LINC00339 expression in U87 and U251 cells after transfection with LINC00339-silencing plasmid. (B) CCK-8 assay was used to evaluate the proliferation effect of LINC00339 on U87 and U251 cells. (C) Three-dimensional culture of U87 and U251 cells after LINC00339 knockdown was calculated (magnification, 100×; scale bar, 100 μm). (D) Migration and invasion of U87 and U251 cells after LINC00339 knockdown were measured (magnification, 200×; scale bar, 100 μm). (E) Western blot analysis was to evaluate the effect after LINC00339 knockdown on the protein expression of MMP-2 and MMP-14 in U87 and U251 cells. Data represent means ± SD (n = 5, each). *p < 0.05 versus shNC group. **p < 0.01 versus shNC group.