Table 1. The peak amplitude of the change-related auditory response.
Left | Right | |||||||
---|---|---|---|---|---|---|---|---|
Placebo | Pre | Post | Pre | Post | ||||
Prepulse | Amplitude | %PPI | Amplitude | %PPI | Amplitude | %PPI | Amplitude | %PPI |
Test alone | 33.3(9.3) | 30.0(10.7) | 31.4(8.9) | 28.7(7.2) | ||||
10ms | 29.9(8.9) | 9.4(12.4) | 30.4(10.3) | -2.9(16.3) | 24.7(8.2) | 21.8(11.1) | 25.4(3.7) | 8.5(17.0) |
20ms | 25.3(10.4) | 25.4(14.8) | 24.2(9.2) | 19.2(12.4) | 23.7(7.5) | 24.3(12.5) | 23.3(6.3) | 18.0(12.7) |
30ms | 26.6(7.8) | 18.0(17.7) | 22.5(6.3) | 22.4(13.8) | 24.4(7.6) | 21.6(12.1) | 20.7(6.8) | 28.2(11.9) |
40ms | 23.0(7.4) | 28.8(19.3) | 21.2(7.7) | 28.7(13.5) | 24.1(6.6) | 22.3(14.7) | 20.4(5.0) | 25.5(24.0) |
50ms | 23.7(9.3) | 27.8(19.9) | 20.5(8.9) | 32.1(11.3) | 22.3(7.2) | 29.1(8.4) | 21.5(6.2) | 23.5(18.5) |
60ms | 22.7(9.2) | 30.6(21.8) | 23.3(10.9) | 22.8(23.9) | 22.6(5.4) | 25.4(16.5) | 21.0(8.6) | 25.9(30.0) |
70ms | 24.5(8.8) | 23.9(24.2) | 24.0(12.8) | 23.1(23.5) | 26.8(9.2) | 15.2(11.6) | 24.0(7.7) | 14.0(26.3) |
Diazepam | ||||||||
Test alone | 30.9(11.0) | 28.9(8.7) | 32.3(8.5) | 27.5(9.0) | ||||
10ms | 29.1(9.0) | 2.5(20.4) | 23.8(7.3) | 16.3(16.1) | 28.9(7.9) | 6.5(30.8) | 25.6(8.1) | 5.6(11.7) |
20ms | 26.0(10.8) | 16.8(13.4) | 21.2(6.7) | 26.8(6.0) | 26.4(7.9) | 16.3(18.6) | 21.4(7.6) | 22.0(11.6) |
30ms | 23.8(9.3) | 23.0(10.9) | 19.2(7.7) | 33.1(18.0) | 22.7(7.3) | 29.4(15.2) | 21.5(11.9) | 25.2(19.3) |
40ms | 20.9(8.7) | 32.3(11.3) | 17.4(5.5) | 38.5(12.0) | 23.5(5.8) | 26.0(13.4) | 18.8(8.2) | 30.8(16.5) |
50ms | 23.4(10.2) | 24.4(16.0) | 18.9(7.3) | 33.2(19.8) | 23.7(7.2) | 26.0(15.2) | 19.6(8.3) | 28.3(21.6) |
60ms | 22.5(8.9) | 25.7(19.8) | 21.2(6.7) | 24.1(21.5) | 24.8(6.9) | 21.1(19.9) | 21.4(7.9) | 22.2(13.8) |
70ms | 22.8(13.4) | 30.6(32.2) | 22.0 (8.0) | 23.1(16.3) | 24.7(7.8) | 22.6(19.9) | 24.0(9.2) | 13.5(17.5) |
Baclofen | ||||||||
Test alone | 29.4(11.2) | 31.0(11.4) | 30.9(11.3) | 30.3(12.1) | ||||
10ms | 24.9(9.9) | 12.2(23.5) | 27.0(9.2) | 11.6(14.1) | 23.4(9.5) | 23.5(19.1) | 25.2(7.5) | 10.6(22.6) |
20ms | 21.9(10.3) | 26.7(14.0) | 23.0(10.7) | 26.4(22.5) | 23.7(9.1) | 19.9(26.2) | 21.9(8.2) | 26.0(15.8) |
30ms | 23.6(9.1) | 19.8(15.5) | 22.8(6.7) | 23.7(14.8) | 23.4(7.5) | 21.4(18.1) | 21.5(9.5) | 27.3(17.2) |
40ms | 18.5(9.7) | 37.4(16.3) | 23.0(9.5) | 26.5(10.7) | 18.9(9.3) | 39.8(12.3) | 22.2(7.4) | 21.9(20.2) |
50ms | 20.2(10.9) | 31.9(18.8) | 22.8(9.4) | 27.1(13.0) | 17.9(5.2) | 39.1(14.7) | 23.8(9.5) | 19.8(16.6) |
60ms | 19.1(9.9) | 36.2(19.8) | 21.5(12.2) | 33.2(24.9) | 19.7(8.3) | 36.8(9.9) | 21.5(10.2) | 30.1(16.7) |
70ms | 19.8(8.5) | 32.3(15.6) | 22.4(11.7) | 29.0(26.4) | 21.8(6.7) | 26.7(15.0) | 23.3(10.0) | 20.5(25.9) |
Amplitudes (nAm) are shown as the mean (SD)