Table 2.
The cross-sectional associations of sex hormone levels with adjusted difference in LV parameters at the MESA baseline exam (2000–2002) [N=4,162]a,b
| Sex hormones | Model 1c | Model 2c | ||||
|---|---|---|---|---|---|---|
|
| ||||||
| LV Mass (g) | LV EDV (ml) | M: V ratio (%) | LV Mass (g) | LV EDV (ml) | M: V ratio (%) | |
|
| ||||||
| A. Women (N= 1,941) | ||||||
| Total T | 0.42 (−0.004, 0.84) | 0.02 (−0.44, 0.48) | 0.37 (−0.03, 0.77) | 0.31 (−0.08, 0.71) | 0.01 (−0.44, 0.46) | 0.29 (−0.10, 0.68) |
| E2 | −0.04 (−0.41, 0.32) | −0.12 (−0.51, 0.27) | 0.12 (−0.23, 0.46) | −0.20 (−0.54, 0.14) | −0.23 (−0.62, 0.15) | 0.07 (−0.27, 0.40) |
| DHEA | 0.78 (0.14, 1.42) | 0.31 (−0.38, 1.00) | 0.55 (−0.06, 1.16) | 0.69 (0.09, 1.29) | 0.31 (−0.37, 0.99) | 0.49 (−0.10, 1.08) |
| Free T | 0.16 (−0.30, 0.63) | −1.19 (−1.68, −0.69) | 1.34 (0.90, 1.77) | −0.03 (−0.49, 0.43) | −0.88 (−1.40, −0.37) | 0.92 (0.47, 1.37) |
| SHBG | −0.16 (−0.71, 0.39) | 1.43 (0.85, 2.01) | −1.58 (−2.09, −1.07) | 0.08 (−0.46, 0.62) | 1.08 (0.47, 1.69) | −1.08 (−1.62, −0.55) |
|
| ||||||
| B. Men (N= 2,221) | ||||||
| Total T | 0.69 (−0.17, 1.55) | 1.85 (0.85, 2.85) | −0.83 (−1.56, −0.10) | 0.75 (−0.07, 1.56) | 1.68 (0.69, 2.67) | −0.65 (−1.37, 0.07) |
| E2 | −0.79 (−1.68, 0.09) | −1.56 (−2.59, −0.52) | 0.76 (0.01, 1.52) | −0.94 (−1.78, −0.10) | −1.36 (−2.38, −0.34) | 0.50 (−0.25, 1.24) |
| DHEA | −0.44 (−1.45, 0.57) | −0.22 (−1.39, 0.95) | −0.24 (−1.09, 0.62) | −0.20 (−1.16, 0.76) | −0.04 (−1.20, 1.12) | −0.21 (−1.06, 0.64) |
| Free T | 0.08 (−0.90, 1.06) | −1.17 (−2.30, −0.04) | 1.29 (0.46, 2.11) | −0.05 (−1.00, 0.90) | −0.47 (−1.61, 0.67) | 0.65 (−0.18, 1.49) |
| SHBG | 0.12 (−0.87, 1.10) | 1.56 (0.42, 2.69) | −1.37 (−2.20, −0.54) | 0.27 (−0.69, 1.22) | 0.87 (−0.27, 2.02) | −0.73 (−1.57, 0.11) |
Abbreviations: MESA, Multi-Ethnic Study of Atherosclerosis; T, testosterone; E2, estradiol; DHEA, dehydroepiandrosterone; SHBG, sex hormone binding globulin; LV, left ventricular; EDV, end-diastolic volume; M:V, Mass: Volume; HDL, high density lipoprotein
Per 1 SD of log Sex Hormone (nmol/L or %). Results presented as β coefficients (95% confidence interval). Bolded results are statistically significant (p <0.05)
Model 1 adjusts for age, race/ethnicity, site, education, baseline physical activity, baseline smoking, baseline height, baseline weight (women: additionally, adjusted for hormone therapy, and years since menopause)
Model 2 additionally adjusts for baseline systolic blood pressure, use of anti-hypertensive medication, total cholesterol, HDL cholesterol, lipid lowering medication and diabetes mellitus.