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. Author manuscript; available in PMC: 2019 Feb 1.
Published in final edited form as: Exp Neurol. 2017 Nov 26;300:247–258. doi: 10.1016/j.expneurol.2017.11.011

Figure 3. A delay longer than 1 day is necessary, while increased or repeated stimulation do not have additional growth-promoting effects.

Figure 3

(A) Neurite growth of DRGs (L4-L6) isolated 1 day after ES is not enhanced (n=6, t-test p=0.68, mean ± SEM). DRGs (L4-L6) isolated (B) 7 days after a single 7h stimulation or (C) after daily 1h stimulations for 7 days show significantly increased neurite growth (n=5–8, t-test *p<0.05; mean ± SEM), but the effect size is similar to single 1h stimulation (compare to Fig.2). (D) For repeated stimulations (n=7, ANOVA p<0.01, Dunnett’s multi comparison test, *p<0.05), motor thresholds were determined on a daily basis, noticing a significant increase in the first 2 days post-surgery, with a return to baseline at later time points.