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. Author manuscript; available in PMC: 2018 Sep 1.
Published in final edited form as: Cytoskeleton (Hoboken). 2017 Jul 24;74(9):356–366. doi: 10.1002/cm.21386

Figure 5. The velocities of multiple-kinesin cargos have a significant but small difference between GMPCPP and GDP microtubules (MTs).

Figure 5

Taxol (25 μM) was present in motility measurements for both MT types. These velocity measurements correspond to run-length measurements in Figure 2A(iii). Solid lines, best fits to the cumulative probability distribution of a Gaussian distribution. Mean velocity (± standard error) and sample size (n) are indicated. For both MT types, the velocities of multiple-kinesin cargos are somewhat lower than that of single-kinesin cargos shown in Figure 4. This reduction in velocity with increasing motor number per cargo is consistent with recent in vitro findings by ourselves [Xu et al., 2013] and others [Conway et al., 2012]. Mean velocity of multiple-kinesin cargos was 1.07× faster on GMPCPP MTs than on GDP MTs (P = 0.004, Student’s t-test).