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. Author manuscript; available in PMC: 2018 Dec 18.
Published in final edited form as: Vaccine. 2017 Nov 7;35(51):7174–7180. doi: 10.1016/j.vaccine.2017.10.078

Figure 5. Anti- P. aeruginosa humoral immune responses and enhanced P. aeruginosa clearance from lungs after the immunization with AdC7OprF.RGD in rats with established P. aeruginosa respiratory infection.

Figure 5

Rats (Sprague Dawley) were immunized intranasally with either 5×1010 particle units of AdC7OprF.RGD or AdC7Null 1 day after the administration of P. aeruginosa embedded in agar beads. Two weeks after the immunization, anti-OprF IgG antibody titers were determined in serum and P. aeruginosa bacterial loads were determined in lung homogenates. A. Serum anti-OprF IgG. B. P. aeruginosa bacterial loads in lung homogenates. Data are presented as mean ± SEM of n=5 mice per group. * and ** denote significance of p < 0.05 and p < 0.01 respectively.