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. 2017 Nov 27;41(2):908–914. doi: 10.3892/ijmm.2017.3290

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Copyright: © Chen et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Effects of PPS on phospho-p38 MAPK and NF-κB p65 expression in cultured HK-2 cells. (A) Western blot analysis of phospho-p38 MAPK and NF-κB p65 activities in HK-2 cells. (B) Densitometric data of protein analysis. NG: 5.5 mmol/l D-glucose; HG: 30 mmol/l D-glucose; NG + PPS: 5.5 mmol/l D-glucose plus 200 µg/ml PPS; and HG + PPS: 30 mmol/l D-glucose plus 200 µg/ml PPS. Data are presented as the means from triplicate determinations (means ± standard deviation) indicated by the vertical bars (^*P<0.05, ^**P<0.01 vs. NG and ^##P<0.01 vs. HG). PPS, pentosan poly-sulfate; p38 MAPK, p38 mitogen-activated protein kinase; NF-κB, nuclear factor-κB; NG, normal glucose, HG, high glucose.