Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Nov 24;41(2):659–668. doi: 10.3892/ijmm.2017.3284

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright: © Wang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

PMC Copyright notice

Ultrastructural evidence of EMT. Normal A549 cells can be identified by the presence of LBs in the cytoplasm. In the TGF-β1 group, LBs were degeneration, swollen and with vacuoles. Arrows indicate LBs; magnification, ×7,000. The cell groups were as follows: control, cells cultured in serum-free DMEM; TGF-β1, cells cultured in serum-free DMEM and exposed to 5 ng/ml TGF-β1; SIS3, cells were treated with 3 μM SIS3 (specifc inhibitor of Smad3), which was added 4 h prior to 5 ng/ml TGF-β1 exposure; BMSCs-CM, BMSCs-CM was added prior to 5 ng/ml TGF-β1 exposure. Nu, cell nucleus; LB, lamellar body; EMT, epithelial-mesenchymal transition; TGF-β1, transforming growth factor-β1.