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. 2017 Dec 8;41(2):946–954. doi: 10.3892/ijmm.2017.3314

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Copyright: © Zhang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Identification of differentially expressed circRNA profiles. Differentially expressed circRNAs between CD90⁺ and CD90⁻ cells were analyzed using a high throughput microarray assay. (A) The heat map revealed 274 distinguishable (238 upregulated and 36 downregulated) circRNAs with differential expression between CD90⁺ and CD90⁻ cells. (B) The key signaling pathways for these circRNAs were identified by Kyoto Encyclopedia of Genes and Genomes enrichment analyses and the top 20 are listed; the top three signaling pathways were the metabolic pathway, pathways in cancer, and the P13K-AKT signaling pathway. CD, cluster of differentiation; circRNA, circular RNA; P13K-AKT, phosphoinositide 3-kinase (P13K)-RAC-α serine/threonine-protein kinase.