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. 2017 Dec 21;2(24):e97381. doi: 10.1172/jci.insight.97381

Figure 4. Alveolar injury and regeneration after deletion of Abca3.

Figure 4

(A) Kaplan-Meier curve and statistical analysis (Wilcoxon-Gehan test) for survival of Abca3-cKO mice treated with tamoxifen for 0–8 days. (B) Abca3 mRNA (exon 5–6) expression normalized to β-actin in whole lung from control and Abca3-cKO mice treated with tamoxifen for 4 days with tissue harvest at 4 days to 12 weeks. Data represent Abca3 mRNA with dot plot overlay; n = 5–20 mice/group. *P < 0.05, ***P < 0.0001 compared with control as determined by 1-way ANOVA. (C) Representative lung histology from control and Abca3-cKO mice treated with tamoxifen for 4 days with tissue harvest at 4 days to 12 weeks. Lung tissue from n = 6–8 mice/group were stained by H&E for histological analysis. Scale bars: 500 μm.