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. 2017 Nov 2;2(21):e93764. doi: 10.1172/jci.insight.93764

Figure 1. NOTCH3 is expressed in perivascular and lumenal cells in IHs.

Figure 1

Serial sections of proliferating and involuting infantile hemangioma (IH) specimens were stained. (A) GLUT1 and CD31 costaining. White arrowheads mark GLUT1+CD31+ cells. Proliferating IH n = 2, involuting IH n = 3. (B) GLUT1 and αSMA costaining. Yellow arrowheads mark αSMA+GLUT1– perivascular cells. Proliferating IH n = 2, involuting IH n = 7. (C) NOTCH3 and CD31 costaining. White arrowheads mark NOTCH3+CD31+ cells. Yellow arrowheads mark NOTCH3+CD31– cells. Proliferating IH n = 4, involuting IH n = 5. (D) NOTCH3 and αSMA costaining. White arrowheads mark NOTCH3+αSMA+ perivascular cells. Yellow arrowheads mark NOTCH3+αSMA– lumenal cells. Proliferating IH n = 5, involuting IH n = 8. Scale bars: 50 μm. The total number of IH specimens assessed for each antigen is presented in Supplemental Table 3. αSMA, α smooth muscle actin; GLUT1, glucose transporter 1.