Figure 8. A subset of minimal change disease patients has activated glomerular STAT6.

Representative immunohistochemistry of glomerular pSTAT6 expression in selected MCD patients (described in Supplemental Table 1) and a control. Ten of twenty-nine MCD patients screened demonstrated pSTAT6 staining (untreated MCD, arrows point to stained nuclei). Twenty-two of twenty-three healthy controls had no detectable pSTAT6 staining. Of 29 MCD patient samples stained for pSTAT6, 2 were strongly positive, 8 were weakly positive, and 19 were negative; of 22 controls samples stained for pSTAT6, 1 was weakly positive and 22 were negative (P = 0.019). Original magnification, ×400.I