Figure 2. Neutralizing titers of PDK53-immune serum against D2Y98P-PP1.

(A) PRNT₅₀ titers of adult A129 mice (n = 5) vaccinated with PDK53 against heterologous DENV2 strain D2Y98P-PP1. Sera were pooled at each time point. Limit of detection is indicated by horizontal dashed line. (B) PRNT₅₀ titers of pups (n = 4) born to PDK53-immunized dams against D2Y98P-PP1. Sera were pooled at each time point. (C) Serum IgG titers of adult PDK53-vaccinated mice against strains 16681 and D2Y98P-PP1. Each data point represents 1 mouse; short lines represent medians and interquartile ranges. Wilcoxon signed-rank test was used to compare anti-16681 (α16681) and αD2Y98P-PP1 IgG titers at each time point. ns, P > 0.05. Data are representative of 2 independent experiments.