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. 2017 Nov 16;2(22):e97152. doi: 10.1172/jci.insight.97152

Figure 2. Pimozide reduce motor defects in C. elegans and zebrafish expressing mutant TDP-43.

Figure 2

(A) Pimozide reduced mTDP-43–induced paralysis in worms at 3 doses (2 μM [n = 109], 20 μM [n = 115], and 40 μM [n = 111]) compared with untreated control (n = 125) (P < 0.001). (B) Pimozide reduced degeneration of motor neuron in mTDP-43 transgenic worms. ***P < 0.001 (n = 4 batches, each batch consisted a quantification of 100 worms). (C) Representative traces of touch-evoked escape response phenotypes in wtTDP-43, mTDP-43, and mTDP-43+pimozide. Application of pimozide (1 μM) led to a significant improvement in the distance swam (D), swim duration (E), and maximum swimming velocity (F) of mTDP43 (n = 16). Data are represented as mean ± SEM. Significant difference from wtTD-P43, *P < 0.001; significantly different from mutant fish, #P < 0.05. All data values are given as mean ± SEM. Significance was determined using one-way ANOVA and Fisher LSD tests for normally distributed and equal variance data; Kruskal-Wallis ANOVA and Dunn’s method of comparison were used for nonnormal distributions.