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. 2017 Nov 16;2(22):e92522. doi: 10.1172/jci.insight.92522

Figure 1. Therapeutic efficacy of various A20 lysate vaccine formulations.

Figure 1

(A) Time line for therapeutic immunization and tumor rechallenge studies in 1-day preestablished A20 B cell lymphoma model. (B) Kaplan-Meier curve (n = 6–10 per group) showing survival for A20 tumor lysate formulation–vaccinated mice (at 100 μg lysate protein/mouse, s.c.) after 2 lethal A20 tumor challenges (dose, 1 × 105 cells/mouse, i.p., on day 1, rechallenged with 2 × 105 cells/mouse, i.p., on day 80) in a therapeutic immunization setting. *P < 0.05, **P < 0.01, log-rank (Mantel-Cox) test. (C) Time line for therapeutic immunization in 7-day preestablished A20 B cell lymphoma model. (D) Kaplan-Meier survival curve for various A20 tumor lysate formulation–injected BALB/C mice (n = 10 per group) following lethal A20 tumor challenges with 2 × 105 cells, i.p.