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. 2017 Nov 16;2(22):e92724. doi: 10.1172/jci.insight.92724

Figure 1. CSF lymphocytes are dominated by T cells, but B cells are disproportionately increased in active MS.

Figure 1

While most CSF lymphocytes are T cells, the overall proportion of B cells (CD19) (A) but not of T cells (CD3) (B) is significantly increased in Gd+ versus Gd– patients. Reflective of an inflammatory state during active MS, the absolute numbers of both B cells (C) and T cells (D) are increased in Gd+ patients. However, there is a disproportionate increase in B cells versus T cells in active disease, as indicated by a significantly higher B/T cell ratio, based on cell number per ml in Gd+ patients (E). Shown are data from patients with active MS (Gd+ lesions on brain MRI) and without Gd-enhancing (Gd–) lesions. Refer to Supplemental Table 1 for more information on the patients analyzed. Data are shown as scatter plots with mean ± 95% CI. Comparisons were made using an unpaired t test (GraphPad Prism); **P < 0.01, ****P < 0.0001.