Table 1. Relationship between CDK5 levels and clinicopathological variables in HCC from our institution.
| Variables | n | Expression of CDK5 (%) | χ2 value | P value | ||
|---|---|---|---|---|---|---|
| Negative | Positive | |||||
| Tissue types | Normal liver | 33 | 23 (69.7) | 10 (30.3) | 53.450 | <0.001 |
| Cirrhosis | 37 | 23 (62.2) | 14 (37.8) | |||
| Adjacent non-cancerous liver | 171 | 96 (56.1) | 75 (43.9) | |||
| HCC | 171 | 40 (23.4) | 131 (76.6) | |||
| Gender | Male | 153 | 35 (22.9) | 118 (77.1) | 0.216 | 0.768 |
| Female | 18 | 5 (27.8) | 13 (72.2) | |||
| Differentiation | High | 20 | 12 (60.0) | 8 (40.0) | 17.161 | <0.001 |
| Moderate | 98 | 17 (17.3) | 81 (82.7) | |||
| Low | 53 | 11 (20.8) | 42 (79.2) | |||
| Size | <5 cm | 58 | 19 (32.8) | 39 (67.2) | 4.297 | 0.055 |
| ≥5 cm | 113 | 21 (18.6) | 92 (81.4) | |||
| Tumor nodes | Single | 68 | 13 (19.1) | 55 (80.9) | 0.163 | 0.819 |
| Multiple | 61 | 10 (16.4) | 51 (83.6) | |||
| Metastasis | - | 90 | 38 (42.2) | 52 (57.8) | 37.595 | <0.001 |
| + | 81 | 2 (2.5) | 79 (97.5) | |||
| Clinical TNM stage | I-II | 48 | 22 (45.8) | 26 (54.2) | 18.754 | <0.001 |
| III-IV | 123 | 18 (14.6) | 105 (85.4) | |||
| Portal vein tumor embolus | - | 84 | 21 (25.0) | 63 (75.0) | 8.451 | 0.003 |
| + | 45 | 2 (4.4) | 43 (95.6) | |||
| Vaso-invasion | - | 77 | 20 (26.0) | 57 (74.0) | 8.649 | 0.004 |
| + | 52 | 3 (5.8) | 49 (94.2) | |||
| Tumor capsular infiltration | With complete capsule | 61 | 12 (19.7) | 49 (80.3) | 0.268 | 0.650 |
| Infiltration or no capsule | 68 | 11 (16.2) | 57 (83.8) | |||
| AFP | - | 56 | 12 (21.4) | 44 (78.6) | 0.146 | 0.813 |
| + | 54 | 10 (18.5) | 44 (81.5) | |||
| Cirrhosis | - | 74 | 13 (17.6) | 61 (82.4) | 2.469 | 0.145 |
| + | 97 | 27 (27.8) | 70 (72.2) | |||