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. 2017 Nov 26;8(65):108418–108429. doi: 10.18632/oncotarget.22664

Figure 8.

Figure 8

Montelukast down-regulate the expression of IL-17A gene in CIA mice. A. Leukocytes in peripheral blood were isolated from naive mouse, CIA animals treated with montelukast (30 mg/kg) or vehicle control at weeks 9 post booster immunization, IL-17A, IFN-γ, IL-1β and TGF-β gene are analyzed by qPCR. B. Hind paw of naive mouse, CIA animals treated with montelukast (30 mg/kg) or vehicle control at weeks 9 post booster immunization homogenate. RNA was isolated and IL-17A, IFN-γ, IL-1β and TGF-β gene are analyzed by qPCR. Data are presented as mean ± SEM (n = 3) and are representative of three independent experiments (. *p < 0.05, **p < 0.01, versus control (two-way ANOVA test).