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. 2017 Sep 18;8(65):108556–108570. doi: 10.18632/oncotarget.20998

Figure 6. Phospho-mimetic T172D mutant of Rab37 lost its metastasis suppression ability in vivo.

Figure 6

(A) The lung images from nude mice 6 weeks after injection of PC-14 cells stably expressing EV-, WT- or T172D-Rab37 via the tail vein. (B) and (C) H&E staining shows more lung colonization and bigger tumor mass in EV control and T172D groups compared with WT group (B) (Original magnification: 200×). Numbers of tumor nodules are shown in the histogram plot (C). P-values were calculated by two-tailed Student’s t-test. Data represented mean ± SD. (n = 5–6 mice/group). (D) Lung tissues from EV-, WT- or T172D-injected nude mice were collected 6 weeks post-injection and subjected to immunohistochemistry to examine the expression of Rab37 and TIMP1. Enlarged images of insets are shown (Original magnification: 200×).