. 2017 Oct 30;8(65):108802–108809. doi: 10.18632/oncotarget.22163

Table 1. Energy intake, body weight, lipids, apoA5, glucose, insulin, HOMA-IR, ALT and AST of mice after four weeks of high fat diet with or without low/high dose metformin.

	Control	NAFLD	Low-dose metformin	High-dose metformin
Energy intake (kcal)	13.28 ± 1.59	19.60 ± 2.35¹	16.82 ± 2.02^{1, 2}	15.48 ± 1.85^{1, 2, 3}
Body weight (g)	25.12 ± 1.56	57.26 ± 3.07¹	45.76 ± 2.60^{1, 2}	40.05 ± 2.35^{1, 2, 3}
Cholesterol (mmol/L)	2.68 ± 0.22	6.05 ± 0.43¹	4.86 ± 0.35^{1, 2}	4.25 ± 0.32^{1, 2, 3}
TG (mmol/L)	1.20 ± 0.09	3.12 ± 0.35¹	2.35 ± 0.26^{1, 2}	2.04 ± 0.22^{1, 2, 3}
ApoA5 (ng/mL)	112.50 ± 13.48	272.40 ± 29.77¹	218.05 ± 24.25 ^{1, 2}	192.68 ± 20.89 ^{1, 2, 3}
Glucose (mmol/L)	6.24 ± 0.33	17.14 ± 0.87¹	13.79 ± 0.72^{1, 2}	10.97 ± 0.55 ^{1, 2, 3}
Insulin (mU/L)	10.05 ± 0.42	23.45 ± 1.18¹	16.88 ± 0.85^{1, 2}	13.83 ± 0.70 ^{1, 2, 3}
HOMA-IR	2.79 ± 0.13	17.82 ± 0.91¹	10.35 ± 0.52^{1, 2}	6.76 ± 0.34 ^{1, 2, 3}
ALT (U/L)	24.52 ± 2.23	162.59 ± 8.12¹	83.09 ± 3.89 ^{1, 2}	71.38 ± 3.62 ^{1, 2, 3}
AST (U/L)	20.78 ± 1.89	180.62 ± 9.83¹	118.63 ± 5.75 ^{1, 2}	79.29 ± 4.02 ^{1, 2, 3}

^{1, 2, 3} Values were significantly different from control, NAFLD and low-dose metformin group, respectively (p < 0.05).