Table 4. Genotypic model analysis of relationship between SNPs and ONFH risk.
| SNPs | Model | Genotype | Group=control | Group=hormone | Without adjustment | With adjustment | AIC | BIC | ||
|---|---|---|---|---|---|---|---|---|---|---|
| OR (95% CI) | pa-value | OR (95% CI) | pa-value | |||||||
| rs650108 | Codominant | A/A | 153 (30.3%) | 216 (37%) | 1.00 | 0.065 | 1.00 | 0.058 | 1461.8 | 1486.8 |
| A/G | 265 (52.5%) | 279 (47.8%) | 0.75 (0.57-0.97) | 0.73(0.55-0.96) | ||||||
| G/G | 87 (17.2%) | 89 (15.2%) | 0.72 (0.51-1.04) | 0.74 (0.51-1.07) | ||||||
| Dominant | A/A | 153 (30.3%) | 216 (37%) | 1.00 | 0.02* | 1.00 | 0.017* | 1459.8 | 1479.8 | |
| A/G-G/G | 352 (69.7%) | 368 (63%) | 0.74 (0.57-0.95) | 0.73(0.56-0.95) | ||||||
| Recessive | A/A-A/G | 418 (82.8%) | 495 (84.8%) | 1.00 | 0.37 | 1.00 | 0.5 | 1465 | 1485 | |
| G/G | 87 (17.2%) | 89 (15.2%) | 0.86 (0.63-1.19) | 0.89 (0.64-1.24) | ||||||
| Overdominant | A/A-G/G | 240 (47.5%) | 305 (52.2%) | 1.00 | 0.12 | 1.00 | 0.08 | 1462.4 | 1482.4 | |
| A/G | 265 (52.5%) | 279 (47.8%) | 0.83 (0.65-1.05) | 0.80 (0.63-1.03) | ||||||
| Log-additive | — | — | — | 0.83 (0.70-0.99) | 0.037* | 0.83 (0.70-1.00) | 0.044* | 1461.5 | 1481.4 | |
| rs522616 | Codominant | T/T | 212 (41.9%) | 224 (38.3%) | 1 | 1 | 0.052 | 1464.3 | 1489.2 | |
| T/C | 230 (45.5%) | 259 (44.3%) | 1.07 (0.82-1.38) | 0.078 | 1.08 (0.83-1.40) | |||||
| C/C | 64 (12.7%) | 102 (17.4%) | 1.51 (1.05-2.17) | 1.57(1.08-2.29) | ||||||
| Dominant | T/T | 212 (41.9%) | 224 (38.3%) | 1 | 0.23 | 1 | 0.19 | 1466.4 | 1486.4 | |
| T/C-C/C | 294 (58.1%) | 361 (61.7%) | 1.16 (0.91-1.48) | 1.18 (0.92-1.52) | ||||||
| Recessive | T/T-T/C | 442 (87.3%) | 483 (82.6%) | 1 | 0.027* | 1 | 0.018* | 1462.6 | 1482.5 | |
| C/C | 64 (12.7%) | 102 (17.4%) | 1.46 (1.04-2.05) | 1.52(1.07-2.14) | ||||||
| Overdominant | T/T-C/C | 276 (54.5%) | 326 (55.7%) | 1 | 0.7 | 1 | 0.69 | 1468 | 1488 | |
| T/C | 230 (45.5%) | 259 (44.3%) | 0.95 (0.75-1.21) | 0.95 (0.75-1.21) | ||||||
| Log-additive | — | — | — | 1.19 (1.00-1.41) | 0.048* | 1.21(1.02-1.44) | 0.033* | 1463.6 | 1483.6 | |
*p ≤ 0.05 indicates statistical significance.
p values were calculated by Wald test by unconditional logistic regression adjusted for age and gender.
AIC, Akaike’s Information criterion; BIC, Bayesian Information criterion.