Table 2. Primary information for TCF7L2 rs7903146C>T, rs290481 T>C, LEP rs7799039 A>G, rs2167270 G>A and LEPR rs1137100 G>A, rs1137101 G>A and rs6588147 G>A polymorphisms.
Genotyped SNPs | Chromosome | Chr Pos (NCBI Build 37) | Region | MAFa for Chinese in database | MAF in our controls (n = 1, 496) | P value for HWEb test in our controls | Genotyping method | Genotyping value (%) |
---|---|---|---|---|---|---|---|---|
TCF7L2 rs7903146 C>T | 10 | 114758349 | Intron 4 | 0.026 | 0.031 | 0.733 | SNPscan | 99.50 |
TCF7L2 rs290481 T>C | 10 | 114923825 | Intron 13 | 0.405 | 0.387 | 0.097 | SNPscan | 99.45 |
LEP rs7799039 A>G | 7 | 127878783 | Promoter | 0.201 | 0.266 | 0.543 | SNPscan | 99.50 |
LEP rs2167270 G>A | 7 | 127881349 | 5’ UTR | 0.175 | 0.222 | 0.324 | SNPscan | 99.40 |
LEPR rs1137100 G>A | 1 | 66036441 | Exon 4 | 0.169 | 0.160 | 0.316 | SNPscan | 99.50 |
LEPR rs1137101 G>A | 1 | 66058513 | Exon 6 | 0.111 | 0.122 | 0.763 | SNPscan | 99.50 |
LEPR rs6588147 G>A | 1 | 65935494 | Intron 2 | 0.150 | 0.150 | 0.260 | SNPscan | 99.50 |
a MAF: minor allele frequency.
b HWE: Hardy–Weinberg equilibrium.