Table 3. Logistic regression analyses of association between TCF7L2 rs7903146C>T, rs290481 T>C, LEP rs7799039 A>G, rs2167270 G>A and LEPR rs1137100 G>A, rs1137101 G>A and rs6588147 G>A polymorphisms and risk of ESCC.
| Genotype | ESCC cases (n=507) | Controls (n=1, 496) | Crude OR (95%CI) | P | Adjusted OR a (95%CI) | P | ||
|---|---|---|---|---|---|---|---|---|
| n | % | n | % | |||||
| TCF7L2 rs7903146C>T | ||||||||
| CC | 475 | 94.25 | 1,399 | 93.96 | 1.00 | |||
| CT | 29 | 5.75 | 89 | 5.98 | 0.96(0.62-1.48) | 0.847 | 1.03(0.65-1.62) | 0.908 |
| TT | 0 | 0 | 1 | 0.07 | - | - | - | - |
| CT+TT | 29 | 5.75 | 90 | 6.04 | 0.95(0.62-1.46) | 0.814 | 1.01(0.64-1.60) | 0.954 |
| CC+CT | 504 | 100.00 | 1488 | 99.93 | 1.00 | 1.00 | ||
| TT | 0 | 0 | 1 | 0.07 | - | - | - | - |
| T allele | 29 | 2.88 | 91 | 3.06 | ||||
| TCF7L2 rs290481 T>C | ||||||||
| TT | 195 | 38.77 | 575 | 38.62 | 1.00 | |||
| TC | 228 | 45.33 | 676 | 45.40 | 0.99(0.79-1.23) | 0.903 | 0.96(0.76-1.22) | 0.748 |
| CC | 80 | 15.90 | 238 | 15.98 | 0.98(0.73-1.33) | 0.911 | 0.99(0.71-1.36) | 0.927 |
| TC+CC | 308 | 61.23 | 914 | 61.38 | 0.99(0.81-1.22) | 0.952 | 0.98(0.78-1.22) | 0.830 |
| TT+TC | 423 | 84.10 | 1,251 | 84.02 | 1.00 | 1.00 | ||
| CC | 80 | 15.90 | 238 | 15.98 | 0.99(0.75-1.31) | 0.967 | 1.01(0.75-1.36) | 0.949 |
| C allele | 388 | 38.57 | 1,152 | 38.68 | ||||
| LEP rs7799039 A>G | ||||||||
| AA | 291 | 57.74 | 797 | 53.53 | 1.00 | 1.00 | ||
| AG | 184 | 36.51 | 591 | 39.69 | 0.85(0.69-1.05) | 0.138 | 0.85(0.67-1.06) | 0.144 |
| GG | 29 | 5.75 | 101 | 6.78 | 0.79(0.51-1.21) | 0.275 | 0.73(0.46-1.17) | 0.191 |
| AG+GG | 213 | 42.26 | 692 | 46.47 | 0.84(0.69-1.03) | 0.101 | 0.83(0.67-1.03) | 0.091 |
| AA+AG | 475 | 94.25 | 1,388 | 93.22 | 1.00 | 1.00 | ||
| GG | 29 | 5.75 | 101 | 6.78 | 0.84(0.55-1.28) | 0.419 | 0.79(0.50-1.24) | 0.300 |
| G allele | 242 | 24.01 | 793 | 26.63 | ||||
| LEP rs2167270 G>A | ||||||||
| GG | 318 | 63.35 | 894 | 60.04 | 1.00 | 1.00 | ||
| GA | 165 | 32.87 | 528 | 35.46 | 0.87(0.70-1.08) | 0.213 | 0.87(0.69-1.09) | 0.220 |
| AA | 19 | 3.78 | 67 | 4.50 | 0.79(0.47-1.34) | 0.382 | 0.81(0.47-1.42) | 0.469 |
| GA+AA | 184 | 36.65 | 595 | 39.96 | 0.87(0.71-1.07) | 0.190 | 0.86(0.69-1.08) | 0.198 |
| GG+GA | 483 | 96.22 | 1,422 | 95.50 | 1.00 | 1.00 | ||
| AA | 19 | 3.78 | 67 | 4.50 | 0.84(0.50-1.40) | 0.496 | 0.86(0.49-1.50) | 0.591 |
| A allele | 203 | 20.22 | 662 | 22.23 | ||||
| LEPR rs1137100 G>A | ||||||||
| GG | 342 | 67.86 | 1,045 | 70.18 | 1.00 | 1.00 | ||
| GA | 147 | 29.17 | 411 | 27.60 | 1.09(0.87-1.37) | 0.448 | 1.08(0.85-1.38) | 0.517 |
| AA | 15 | 2.98 | 33 | 2.22 | 1.39(0.74-2.58) | 0.304 | 1.30(0.67-2.52) | 0.436 |
| GA+AA | 162 | 32.14 | 444 | 29.82 | 1.12(0.90-1.39) | 0.327 | 1.10(0.87-1.39) | 0.417 |
| GG+GA | 489 | 97.02 | 1,456 | 97.78 | 1.00 | 1.00 | ||
| AA | 15 | 2.98 | 33 | 2.22 | 1.35(0.73-2.51) | 0.338 | 1.27(0.66-2.46) | 0.472 |
| A allele | 177 | 17.56 | 477 | 16.02 | ||||
| LEPR rs1137101 G>A | ||||||||
| GG | 390 | 77.38 | 1,146 | 76.96 | 1.00 | 1.00 | ||
| GA | 108 | 21.43 | 322 | 21.63 | 0.98(0.77-1.26) | 0.898 | 0.91(0.70-1.18) | 0.473 |
| AA | 6 | 1.19 | 21 | 1.41 | 0.84(0.34-2.09) | 0.705 | 0.91(0.35-2.37) | 0.848 |
| GA+AA | 114 | 22.62 | 343 | 23.04 | 0.98(0.77-1.24) | 0.848 | 0.91(0.70-1.18) | 0.468 |
| GG+GA | 498 | 98.81 | 1,468 | 98.59 | 1.00 | 1.00 | ||
| AA | 6 | 1.19 | 21 | 1.41 | 0.84(0.34-2.10) | 0.712 | 0.93(0.36-2.42) | 0.884 |
| A allele | 120 | 11.90 | 364 | 12.22 | ||||
| LEPR rs6588147 G>A | ||||||||
| GG | 367 | 72.82 | 1,070 | 71.86 | 1.00 | 1.00 | ||
| GA | 119 | 23.61 | 391 | 26.26 | 0.89(0.70-1.12) | 0.316 | 0.85(0.66-1.09) | 0.199 |
| AA | 18 | 3.57 | 28 | 1.88 | 1.87(1.02-3.43) | 0.042 | 1.82(0.96-3.46) | 0.068 |
| GA + AA | 137 | 27.18 | 419 | 28.14 | 0.95(0.76-1.20) | 0.680 | 0.91(0.72-1.16) | 0.465 |
| GG+GA | 486 | 96.43 | 1,461 | 98.12 | 1.00 | 1.00 | ||
| AA | 18 | 3.57 | 28 | 1.88 | 1.93(1.06-3.53) | 0.031 | 1.90(1.00-3.61) | 0.049 |
| A allele | 155 | 15.38 | 447 | 15.01 | ||||
a Adjusted for age, sex, BMI, alcohol use and smoking status.
Bold values are statistically significant (P <0.05).