Table 4. Stratified analyses between LEP rs7799039 A>G polymorphism and ESCC risk by sex, age, BMI, smoking status and alcohol consumption.
| Variable | LEP rs7799039 A>G (case/control)a | Adjusted ORb (95% CI); P | ||||||
|---|---|---|---|---|---|---|---|---|
| AA | AG | GG | AA | AG | GG | AG/GG | GG vs. (AG/AA) | |
| Sex | ||||||||
| Male | 222/581 | 134/425 | 19/72 | 1.00 | 0.81(0.62-1.06); P: 0.117 |
0.60(0.33-1.06); P: 0.079 |
0.77(0.60-1.00); P: 0.052 |
0.65(0.37-1.15); P: 0.136 |
| Female | 69/216 | 50/166 | 10/29 | 1.00 | 0.97(0.63-1.50); P: 0.901 |
1.324 (0.60-2.97); P: 0.475 |
1.03(0.68-1.55); P: 0.897 |
1.36 (0.62-2.95); P: 0.442 |
| Age | ||||||||
| <63 | 139/395 | 79/306 | 18/46 | 1.00 | 0.78(0.56-1.11); P: 0.166 |
1.31 (0.69-2.50); P: 0.409 |
0.84(0.60-1.16); P: 0.282 |
1.43 (0.76-2.69); P: 0.263 |
| ≥63 | 152/402 | 105/285 | 11/55 | 1.00 | 0.95(0.70-1.29); P: 0.737 |
0.47(0.23-0.95); P: 0.035 |
0.88 (0.65-1.18); P: 0.395 |
0.48 (0.24-0.96); P: 0.038 |
| Smoking status | ||||||||
| Never | 146/589 | 83/427 | 16/70 | 1.00 | 0.79(0.59-1.08); P: 0.135 |
0.99(0.55-1.78); P: 0.970 |
0.83(0.62-1.10); P: 0.190 |
1.09(0.61-1.93); P: 0.779 |
| Ever | 145/208 | 101/164 | 13/31 | 1.00 | 0.92(0.65-1.31); P: 0.637 |
0.49(0.23-1.02); P: 0.057 |
0.84(0.60-1.18); P: 0.306 |
0.50(0.24-1.04); P: 0.063 |
| Alcohol consumption | ||||||||
| Never | 198/706 | 122/526 | 18/91 | 1.00 | 0.82(0.63-1.06); P: 0.135 |
0.72(0.42-1.23); P: 0.229 |
0.81 (0.63-1.04); P: 0.097 |
0.78(0.46-1.33); P: 0.359 |
| Ever | 93/91 | 62/65 | 11/10 | 1.00 | 1.06(0.64-1.77); P: 0.820 |
0.75(0.28-1.96); P: 0.552 |
0.99(0.61-1.60); P: 0.955 |
0.72(0.28-1.85); P: 0.492 |
| BMI (kg/m2) | ||||||||
| <24 | 210/436 | 137/285 | 20/53 | 1.00 | 0.96(0.72-1.26); P: 0.744 |
0.63(0.35-1.13); P: 0.118 |
0.90 (0.69-1.18); P: 0.458 |
0.64(0.36-1.13); P: 0.126 |
| ≥24 | 81/361 | 47/306 | 9/48 | 1.00 |
0.66(0.45-0.99); P: 0.044 |
0.93(0.43-1.99); P: 0.847 |
0.69(0.48-1.01); P: 0.058 |
1.09(0.52-2.31); P: 0.816 |
a For LEP rs7799039 A>G, the genotyping was successful in 507 (99.41%) ESCC cases, and 1,496 (99.53%) controls.
b Adjusted for multiple comparisons [age, sex, BMI, smoking status and alcohol consumption (besides stratified factors accordingly)] in a logistic regression model.