Table 5. Stratified analyses between LEPR rs1137101 G>A polymorphism and ESCC risk by sex, age, BMI, smoking status and alcohol consumption.
| Variable | LEPR rs1137101 G>A (case/control)a | Adjusted ORb (95% CI); P | ||||||
|---|---|---|---|---|---|---|---|---|
| GG | GA | AA | GG | GA | AA | GA/AA | AA vs. (GA/GG) | |
| Sex | ||||||||
| Male | 292/832 | 78/235 | 5/11 | 1.00 | 0.84(0.61-1.15); P: 0.275 |
1.52(0.49-4.75); P: 0.473 |
0.87(0.64-1.18); P: 0.353 |
1.57(0.50-4.91); P: 0.435 |
| Female | 98/314 | 30/87 | 1/10 | 1.00 | 1.11(0.68-1.81); P: 0.686 |
0.27(0.03-2.24); P: 0.226 |
1.02(0.63-1.65); P: 0.943 |
0.27 (0.03-2.20); P: 0.220 |
| Age | ||||||||
| <63 | 177/579 | 55/157 | 4/11 | 1.00 | 1.06 (0.72-1.57); P: 0.772 |
1.77 (0.51-6.13); P: 0.370 |
1.09(0.74-1.59); P: 0.666 |
1.73(0.50-5.98); P: 0.387 |
| ≥63 | 213/567 | 53/165 | 2/10 | 1.00 | 0.75(0.52-1.08); P: 0.123 |
0.43(0.09-2.02); P: 0.283 |
0.74(0.52-1.06); P: 0.097 |
0.46(0.10-2.16); P: 0.323 |
| Smoking status | ||||||||
| Never | 186/848 | 56/221 | 3/17 | 1.00 | 1.15(0.82-1.61); P: 0.432 |
0.72(0.20-2.56); P: 0.613 |
1.12(0.80-1.57); P: 0.504 |
0.70(0.20-2.49); P: 0.585 |
| Ever | 204/298 | 52/101 | 3/4 | 1.00 |
0.66(0.44-1.00); P: 0.049 |
1.51(0.30-7.58); P: 0.616 |
0.68(0.46-1.02); P: 0.063 |
1.65 (0.33-8.24); P: 0.543 |
| Alcohol consumption | ||||||||
| Never | 260/1,028 | 73/276 | 5/19 | 1.00 | 1.00(0.74-1.35); P: 0.999 |
1.04(0.37-2.89); P: 0.943 |
1.01(0.75-1.35); P: 0.953 |
1.04(0.38-2.89); P: 0.939 |
| Ever | 130/118 | 35/46 | 1/2 | 1.00 |
0.54(0.31-0.95); P: 0.031 |
0.56(0.04-8.70); P: 0.679 |
0.54(0.31-0.93); P: 0.027 |
0.64(0.04-9.68); P: 0.750 |
| BMI (kg/m2) | ||||||||
| <24 | 279/600 | 83/165 | 5/9 | 1.00 | 0.99(0.72-1.36); P: 0.930 |
1.32(0.42-4.18); P: 0.633 |
1.01(0.74-1.38); P: 0.972 |
1.33(0.42-4.20); P: 0.623 |
| ≥24 | 111/546 | 25/157 | 1/12 | 1.00 | 0.76(0.47-1.22); P: 0.250 |
0.39(0.05-3.12); P: 0.376 |
0.73(0.45-1.16); P: 0.183 |
0.41(0.05-3.29); P: 0.405 |
a For LEPR rs1137101 G>A, the genotyping was successful in 507 (99.41%) ESCC cases, and 1,496 (99.53%) controls.
b Adjusted for multiple comparisons [age, sex, BMI, smoking status and alcohol consumption (besides stratified factors accordingly)] in a logistic regression model.