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. 2017 Nov 25;8(65):109271–109288. doi: 10.18632/oncotarget.22669

Figure 3. AR (but not HGF/c-Met) mediates the enhancement of androgen-induced ETS-1 activity.

Figure 3

Cells were treated with 100 nM of DHT (A-C, E, F) or 30 ng/ml of HGF (D). HepG2 cells were stably transfected with empty vector (A, D, E), AR vectors (A, D), control siRNA (B, F), AR siRNA (B), ETS-1 vector (E), or ETS-1 siRNA (F), while PC-3 cells were stably transfected with empty vector (C) or AR vectors (C). Then, cells which were co-transfected with EBS-Luc reporters and harvested for Luciferase analysis. The expression of AR and ETS-1 were determined by immunoblots, and the results are shown in the panels at the bottom of the figure. The values are the mean ± SD from triplicate independent experiments. *P < 0.05.