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. 2017 Nov 27;8(65):109332–109339. doi: 10.18632/oncotarget.22675

Table 1. The genotype and allele frequency and odds ratios (OR) of the SOD A35C, CAT C-262T and GSHPX1Pro197Leu polymorphisms in patients with inflammatory bowel disease (IBD) and Crohn’s disease and ulcerative colitis compared to control group.

Controls
n=245
IBD
n=200
OR (95% CI)
p-value
Crohn’s disease
n=95
OR (95% CI)
p-value
Ulcerative colitis
n=95
OR (95% CI)
p-value
SOD A35C genotype
A/A 208 (0.85) 186 (0.93) Ref. 89 (0.94) Ref. 97 (0.92) Ref.
A/C 36 (0.15) 14 (0.07) 0.43(0.23-0.83) p=0.01 6 (0.06) 0.39(0.16-0.96) p=0.034 8 (0.08) 0.48(0.21-1.06) p=0.066
C/C 1 (0.00) 0 (0.00) - 0 (0.00) - 0 (0.00) -
allele
A 452 (0.92) 386 (0.97) Ref. 184 (0.97) Ref. 202 (0.96) Ref.
C 38 (0.08) 14 (0.04) 0.43(0.23-0.81) p=0.007 6 (0.03) 0.39(0.16-0.93) p=0.029 8 (0.04) 0.47(0.22-1.03) p=0.053
CATC-262T genotype
C/C 151 (0.62) 130 (0.65) Ref. 59 (0.62) Ref. 73 (0.70) Ref.
C/T 79 (0.32) 59 (0.30) 0.85(0.38-1.92) p=0.699 30 (0.32) 0.97(0.57-1.63) p=0.92 27 (0.26) 0.71(0.42-1.19) p=0.188
T/T 15 (0.06) 11 (0.06) 0.98(0.42-2.29) p=1.000 6 (0.06) 1.02(0.38-2.76) p=1.000 5 (0.05) 0.69(0.24-1.97) p=0.484
allele
C 381 (0.78) 319 (0.80) Ref. 148 (0.78) Ref. 173 (0.82) Ref.
T 109 (0.22) 81 (0.20) 0.89 (0.64-1.23) p=0.471 42 (0.22) 0.99 (0.66-1.48) p=1.000 37 (0.18) 0.75(0.49-1.13) p=0.167
GSHPX1
Pro197Leu genotype
C/C 46 (0.19)a) 68 (0.34) Ref. 33 (0.34) Ref. 37 (0.36) Ref.
C/T 172 (0.70) 115 (0.58) 0.45(0.29-0.7) p=0.0004 55 (0.57) 0.46(0.26-0.77) p=0.003 58 (0.56) 0.42(0.25-0.71) p=0.001
T/T 27 (0.11) 17 (0.09) 0.43(0.21-0.87) p=0.018 9 (0.09) 0.46(0.19-1.12) p=0.083 8 (0.08) 0.37(0.15-0.91) p=0.027
allele
C 264 (0.54) 251 (0.63) Ref. 121 (0.62) Ref. 132 (0.64) Ref.
T 226 (0.46) 149 (0.37) 0.69(0.53-0.91) p=0.008 73 (0.38) 0.70(0.50-0.99) p=0.043 74 (0.36) 0.65(0.47-0.92) p=0.013

ap<0.05 distribution not consistent with Hardy-Weinberg equilibrium