Table 1. The genotype and allele frequency and odds ratios (OR) of the SOD A35C, CAT C-262T and GSHPX1Pro197Leu polymorphisms in patients with inflammatory bowel disease (IBD) and Crohn’s disease and ulcerative colitis compared to control group.
Controls n=245 |
IBD n=200 |
OR (95% CI) p-value |
Crohn’s disease n=95 |
OR (95% CI) p-value |
Ulcerative colitis n=95 |
OR (95% CI) p-value |
|
---|---|---|---|---|---|---|---|
SOD A35C genotype | |||||||
A/A | 208 (0.85) | 186 (0.93) | Ref. | 89 (0.94) | Ref. | 97 (0.92) | Ref. |
A/C | 36 (0.15) | 14 (0.07) | 0.43(0.23-0.83) p=0.01 | 6 (0.06) | 0.39(0.16-0.96) p=0.034 | 8 (0.08) | 0.48(0.21-1.06) p=0.066 |
C/C | 1 (0.00) | 0 (0.00) | - | 0 (0.00) | - | 0 (0.00) | - |
allele | |||||||
A | 452 (0.92) | 386 (0.97) | Ref. | 184 (0.97) | Ref. | 202 (0.96) | Ref. |
C | 38 (0.08) | 14 (0.04) | 0.43(0.23-0.81) p=0.007 | 6 (0.03) | 0.39(0.16-0.93) p=0.029 | 8 (0.04) | 0.47(0.22-1.03) p=0.053 |
CATC-262T genotype | |||||||
C/C | 151 (0.62) | 130 (0.65) | Ref. | 59 (0.62) | Ref. | 73 (0.70) | Ref. |
C/T | 79 (0.32) | 59 (0.30) | 0.85(0.38-1.92) p=0.699 | 30 (0.32) | 0.97(0.57-1.63) p=0.92 | 27 (0.26) | 0.71(0.42-1.19) p=0.188 |
T/T | 15 (0.06) | 11 (0.06) | 0.98(0.42-2.29) p=1.000 | 6 (0.06) | 1.02(0.38-2.76) p=1.000 | 5 (0.05) | 0.69(0.24-1.97) p=0.484 |
allele | |||||||
C | 381 (0.78) | 319 (0.80) | Ref. | 148 (0.78) | Ref. | 173 (0.82) | Ref. |
T | 109 (0.22) | 81 (0.20) | 0.89 (0.64-1.23) p=0.471 | 42 (0.22) | 0.99 (0.66-1.48) p=1.000 | 37 (0.18) | 0.75(0.49-1.13) p=0.167 |
GSHPX1 | |||||||
Pro197Leu genotype | |||||||
C/C | 46 (0.19)a) | 68 (0.34) | Ref. | 33 (0.34) | Ref. | 37 (0.36) | Ref. |
C/T | 172 (0.70) | 115 (0.58) | 0.45(0.29-0.7) p=0.0004 | 55 (0.57) | 0.46(0.26-0.77) p=0.003 | 58 (0.56) | 0.42(0.25-0.71) p=0.001 |
T/T | 27 (0.11) | 17 (0.09) | 0.43(0.21-0.87) p=0.018 | 9 (0.09) | 0.46(0.19-1.12) p=0.083 | 8 (0.08) | 0.37(0.15-0.91) p=0.027 |
allele | |||||||
C | 264 (0.54) | 251 (0.63) | Ref. | 121 (0.62) | Ref. | 132 (0.64) | Ref. |
T | 226 (0.46) | 149 (0.37) | 0.69(0.53-0.91) p=0.008 | 73 (0.38) | 0.70(0.50-0.99) p=0.043 | 74 (0.36) | 0.65(0.47-0.92) p=0.013 |
ap<0.05 distribution not consistent with Hardy-Weinberg equilibrium