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. 2017 Nov 25;8(65):109478–109486. doi: 10.18632/oncotarget.22695

Figure 2. Placental weight increased and fetal weight and placental efficiency are reduced at E18 by maternal fasting.

Figure 2

(A) ANOVA showed that placental weight is increased by maternal stress (p<0.001) in all 4 conditions. (B) Fetal weight is reduced by maternal stress (p=0.005) in all 4 conditions (averaged across the average for each litter). (C) The ratio of fetal to placenta weight (a surrogate for the efficiency of placental transport) was reduced by maternal stress (p<0.001). This ratio partly adjusts for the interacting effects of litter size in such studies. N=44, 14, 27 and 26 in unstressed and 34, 31, 31 and 35 in stressed offspring from 5, 5, 5 and 5 unstressed and 12, 9, 12 and 14 stressed litters corresponding to control, LPD, NPDAZT and LPDAZT respectively. NPD controls, LPD fed on low protein diet, NPDAZT treated with AZT but on normal diet, LPDAZT fed on low protein diet and treated with AZT. Error bars are 1SE. Calipers represent ANOVA F test p-value for effect of maternal stress, ***p<0.001, **p<0.01.