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. Author manuscript; available in PMC: 2019 Jan 1.
Published in final edited form as: Mol Cancer Res. 2017 Sep 19;16(1):90–102. doi: 10.1158/1541-7786.MCR-17-0153

Figure 2. Assessment of HPV-host fusional breakpoints in fragile and repetitive regions of the human genome.

Figure 2

A. Number of breakpoints in common fragile sites (CFS), rare fragile sites (RFS) and non-fragile regions (NFR), compared to what is expected by chance. HPV is not more prone to integrate into fragile sites in the human genome in HNSCC tumors. B. Number of breakpoints in repetitive regions compared to what is expected by chance. Several repetitive element types (LINE, DNA, LTR and all repeats combined) are determined to be significantly enriched for HPV integrations (Chi-squared test p-values with FDR adjustment = 7.42E-05, 0.015, 8.40E-07, and 4.41E-10 correspondingly). (See also Supplemental Table S6 for a further breakdown by repeat family).