Table 1.
Demographic and clinicopathologic characteristics of HPV-positive patients by virus integration status.
| Parameter | HPV(+) UM tumors | HPV(+)TCGA tumors | p-value | ||||
|---|---|---|---|---|---|---|---|
| Total | Integration-positive | Integration-negative | Total | Integration-positive | Integration-negative | ||
|
| |||||||
| 18 | 9 | 9 | 66 | 42 | 24 | ||
|
| |||||||
| Age at diagnosis | |||||||
| Median (std) | 58 (7.3) | 54 (6.2) | 59 (7.3) | 57 (9.2) | 59 (9.5) | 56 (8.2) | 0.463 |
| Gender | |||||||
| Male | 17 | 9 (100%) | 8 (89%) | 60 | 38 (90%) | 22 (92%) | 1 |
| Female | 1 | 0 | 1 (11%) | 6 | 4 (10%) | 2 (8%) | |
| HPV type | |||||||
| HPV16 | 14 | 7 (78%) | 7 (78%) | 55 | 34 (81%) | 21 (88%) | 0.772 |
| HPV18 | 1 | 1 (11%) | 0 | 0 | 0 | 0 | |
| HPV33 | 1 | 1 (11%) | 0 | 8 | 5 (12%) | 3 (13%) | |
| HPV35 | 2 | 0 | 2 | 3 | 3 (7%) | 0 | |
| Anatomical Site | |||||||
| Oropharynx | 17 | 8 (89%) | 9 (100%) | 47 | 26 (62%) | 21 (88%) | 0.011 |
| Oral Cavity | 1 | 1 (11%) | 0 | 16 | 14 (33%) | 2 (8%) | |
| Larynx | 0 | 0 | 0 | 1 | 1 (2%) | 0 | |
| Hypopharynx | 0 | 0 | 0 | 2 | 1 (2%) | 1 (4%) | |
| Tumor Stage | |||||||
| I–II | 1 | 0 | 1 (11%) | 12 | 6 (14%) | 6 (25%) | 0.439 |
| III | 2 | 0 | 2 (22%) | 7 | 5 (12%) | 2 (8%) | |
| IV | 15 | 9 (100%) | 6 (67%) | 47 | 31 (74%) | 16 (67%) | |
| T stage | |||||||
| T1–T2 | 8 | 3 (33%) | 5 (56%) | 39 | 22 (52%) | 17 (71%) | 0.176 |
| T3–T4 | 10 | 6 (67%) | 4 (44%) | 26 | 19 (45%) | 7 (29%) | |
| N stage | |||||||
| N0 | 1 | 0 | 1 (11%) | 18 | 12 (29%) | 6 (25%) | 0.674 |
| N1 | 2 | 0 | 2 (22%) | 6 | 4 (10%) | 2 (8%) | |
| N2 | 11 | 6 (67%) | 5 (56%) | 39 | 24 (57%) | 15 (63%) | |
| N3 | 4 | 3 (33%) | 1 (11%) | 2 | 2 (2%) | 0 | |
| Smoking Status | |||||||
| Current | 3 | 1 (11%) | 2 (22%) | 13 | 8 (19%) | 5 (21%) | 0.439 |
| Former | 11 | 6 (67%) | 5 (56%) | 30 | 22 (52%) | 8 (33%) | |
| Never | 4 | 2 (22%) | 2 (22%) | 22 | 12 (29%) | 10 (42%) | |
Tests were performed between integration-positive and integration-negative samples for both combined cohorts. For age, Wilcoxon rank sum test was used for age; Fisher’s exact test was used for other variables. For anatomical sites we tested only oropharynx versus oral cavity tumors due to insufficient samples from other sites.