A: Histogram representing the number of patients with each given number of detected alterations. There were 123 patients with characterized alteration(s) (excluding VUSs), and 149 patients with detected alteration(s) (including VUSs). B: Percentage of patients with given number(s) of characterized alterations, separated by most common cancers in data set. All 213 patients were included. Patients for whom all detected alterations were VUS, as well as patients with no alterations were counted as having zero characterized alterations. In some cancers such as hepatocellular carcinoma, the majority of patients (74%) harbor one or more characterized alterations; in contrast, the vast majority (76%) of the patients with appendiceal adenocarcinoma patients had no characterized alterations (either no detected alterations, or all detected were VUS).