Table 2.
Frequency and tissues of origin of patients sharing gene or alteration profiles* (excludes VUS)
| Shared gene profile (N = 60) | Number of patients | Represented histologies in liquid biopsy |
|---|---|---|
| TP53 | 19 | Hepatocellular carcinoma (N = 7), colorectal adenocarcinoma (N = 4), pancreatic ductal adenocarcinoma (N=3), esophageal adenocarcinoma (N = 2), cholangiocarcinoma (N = 1), appendix adenocarcinoma (N = 1), gallbladder carcinoma (N = 1) |
| KRAS | 10 | Colorectal adenocarcinoma (N=4), pancreatic ductal adenocarcinoma (N=2), appendix adenocarcinoma (N=2), cholangiocarcinoma (N=1), pancreatic neuroendocrine tumor (N=1) |
| KRAS, TP53 | 9 | Colorectal adenocarcinoma (N=5), pancreatic ductal adenocarcinoma (N=2), esophageal adenocarcinoma (N=1), GIST (N=1) |
| TP53, KRAS, MYC | 4 | Appendix adenocarcinoma (N=1), colorectal adenocarcinoma (N=1), gastric adenocarcinoma (N=1), pancreatic ductal adenocarcinoma (N=1) |
| RAF1 | 2 | Duodenum adenocarcinoma (N=1), gastric adenocarcinoma (N=1) |
| APC | 2 | Colorectal adenocarcinoma (N=2) |
| GNAS | 2 | Appendix adenocarcinoma (N=1), colorectal adenocarcinoma (N=1) |
| CTNNB1 | 2 | Hepatocellular carcinoma (N=2) |
| KRAS, MYC | 2 | Colorectal adenocarcinoma (N=1), pancreatic ductal adenocarcinoma (N=1) |
| CTNNB1, TP53 | 2 | Hepatocellular carcinoma (N=2) |
| APC, TP53 | 2 | Colorectal adenocarcinoma (N=2) |
| PIK3CA, TP53 | 2 | Colorectal adenocarcinoma (N=1), hepatocellular carcinoma (N=1) |
| APC, KRAS, TP53 | 2 | Colorectal adenocarcinoma (N=2) |
| Shared molecular alteration profile (N = 6) | Number of patients | Represented histologies in liquid biopsy |
| KRAS G12D | 2 | Pancreatic ductal adenocarcinoma (N=1), colorectal adenocarcinoma (N=1) |
| GNAS R201H | 2 | Appendix adenocarcinoma (N=1), colorectal adenocarcinoma (N=1) |
| KRAS G12V | 2 | Appendix adenocarcinoma (N=2) |
| Shared molecular alteration profile (N = 2) | Number of patients | Represented histologies in tissue biopsy |
| KRAS G12R | 2 | Pancreatic ductal adenocarcinoma (N=1), colorectal adenocarcinoma (N=1) |
Abbreviations: VUS = variant of unknown significance, GIST = gastrointestinal stromal tumor
*
Patients sharing gene profiles had the same sets of genes altered, while shared alteration profiles were patients who had the same sets of specific alterations at the same gene.