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. Author manuscript; available in PMC: 2018 Dec 26.
Published in final edited form as: ACS Nano. 2017 Nov 29;11(12):12193–12201. doi: 10.1021/acsnano.7b05428

Figure 4.

Figure 4

In vivo radio-stability study using PET imaging. (a–e) In vivo Maximum intensity projections (MIPs) of mice after i.v. injection of 89Zr-MxOy-PEG nanomaterials: (a) 89Zr-Gd2O3-PEG; (b) 89Zr-TiO2-PEG; (c) 89Zr-Ta2O5-PEG; (d) 89Zr-Y2O3-PEG), and (e) Free 89Zr at different time points. (f&g) Quantitative region of interest (ROI) analysis of the dynamic uptake of 89Zr after i.v. injection of 89Zr-Gd2O3-PEG (f) or free 89Zr (g) in bone and liver. (h) Biodistribution of 89Zr-Gd2O3-PEG and free 89Zr measured at 14 days p.i. Data is presented as the percentage of injected dose per gram of tissue (%ID/g). Sk: Skin; Mu: Muscle; B: Bone; Lu: Lung; L: Liver; K: Kidney; Sp: Spleen; In: Intestine. Error bars are based on the standard error of the mean (SEM) of triplicate samples.