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. Author manuscript; available in PMC: 2019 Jan 1.
Published in final edited form as: Mol Cancer Ther. 2017 Nov 15;17(1):107–118. doi: 10.1158/1535-7163.MCT-16-0922

Figure 3. JQ1 downregulated c-Myc and its downstream targets in a JQ1-sensitive CCA2 model.

Figure 3

(a) JQ1 inhibited c-Myc and cell cycle related gene products in CCA2 tumors. Genes downregulated ≥ 2.4-fold by NanoString analyses are displayed by heatmap. (b) Twenty-four genes downregulated ≥ 2.4-fold were entered into the STRING database and a protein-protein interaction network generated. The red nodes indicate proteins involved in cell cycle regulation.