Table 1. Clinical characteristics of tumor from which CCA PDX models were derived.

The tumor tissue used to generate PDX models were obtained from consented patients undergoing surgical resection (CCA1-CCA4) or biopsy (CCA5) as part of standard of care for treatment of CCA.

ID	TNM1	Stage	Grade	Sub Class	LN2 met	L.I3	P.I.4	pT5 (cm)
CCA1	pT2N1	IIB	G3	EHCC	Y	Y	Y	1.8
CCA2	pT3N0	IIA	G2-G3	EHCC	N	Y	N	3.5
CCA3	pT3N1	IIB	G3	EHCC	Y	Y	Y	1.3
CCA4	pT3N1	IIB	G1	EHCC	Y	N	Y	1.2
CCA5	met6	IV	n/a	IHCC	n/a	n/a	n/a	n/a

¹TNM staging system. T represents the size and extent of the primary tumor; N represents the number of lymph nodes involved; M indicates presence of metastasis.

²Lymph node metastases present: Yes/No

³Lymphovascular invasion

⁴Perineural invasion

⁵Size of primary tumor

⁶Metastases

n/a: not available