Table 2. Changes in clinical parameters at each visit.
| Group | Variable | Visit 1 | Visit 2 | Visit 3 | Visit 4 |
|---|---|---|---|---|---|
| Total (n=127) | CA (yr) | 8.5±0.5 | 9.4±0.5* | 11.3±0.5* | 12.0±0.6* |
| BA (yr) | 10.1±0.7 | 10.9±0.6* | 12.0±0.4* | 12.6±0.7* | |
| Height z score for CA | 1.04±0.78 | 0.97±0.74* | 0.50±0.77* | 0.51±0.90* | |
| Weight z score for CA | 0.72±0.74 | 0.71±0.77 | 0.59±0.85* | 0.52±1.06* | |
| BMI z score for CA | 0.32±0.88 | 0.37±0.90 | 0.44±0.92* | 0.36±0.96 | |
| Height z score for BA | −0.60±0.72 | −0.45±0.60* | −0.16±0.59* | 0.00±0.63* | |
| Weight z score for BA | −0.39±0.85 | −0.19±0.73* | 0.19±0.82* | 0.25±0.78* | |
| BMI z score for BA | −0.01±0.88 | 0.02±0.88* | 0.29±0.93* | 0.24±0.89* | |
| Waist-to-height ratio | 0.459±0.004 | 0.467±0.005* | 0.469±0.005* | 0.466±0.005* | |
| Normal/overweight/obesity | 97/22/8 | 97/22/8 | 97/22/8 | 100/16/11 | |
| Normal weight (n=97) | CA (yr) | 8.5±0.5 | 9.4±0.5* | 11.2±0.5* | 12.0±0.6* |
| BA (yr) | 10.1±0.7 | 10.8±0.6* | 11.9±0.4* | 12.5±0.6* | |
| Height z score for CA | 1.00±0.80 | 0.93±0.76* | 0.45±0.77* | 0.46±0.92* | |
| Weight z score for CA | 0.45±0.60 | 0.45±0.63 | 0.29±0.66* | 0.21±0.96* | |
| BMI z score for CA | −0.06±0.61 | 0.01±0.69 | 0.09±0.70* | 0.00±0.76 | |
| Height z score for BA | −0.62±0.72 | −0.43±0.61* | −0.18±0.60* | 0.04±0.62* | |
| Weight z score for BA | −0.68±0.70 | −0.45±0.57* | −0.11±0.62* | −0.04±0.57* | |
| BMI z score for BA | −0.47±0.61 | −0.32±0.66* | −0.07±0.70* | −0.10±0.67* | |
| Waist-to-height ratio | 0.440±0.003 | 0.448±0.004* | 0.453±0.004* | 0.447±0.004 | |
| Overweight and obesity (n=30) | CA (yr) | 8.5±0.5 | 9.5±0.5* | 11.4±0.5* | 12.1±0.6* |
| BA (yr) | 10.2±0.8 | 11.1±0.5* | 12.2±0.3* | 13.0±0.7* | |
| Height z score for CA | 1.15±0.72 | 1.07±0.69* | 0.65±0.76* | 0.68±0.82* | |
| Weight z score for CA | 1.61±0.40 | 1.56±0.54 | 1.57±0.62 | 1.54±0.65 | |
| BMI z score for CA | 1.54±0.36 | 1.51±0.47 | 1.59±0.55 | 1.50±0.54 | |
| Height z score for BA | −0.53±0.74 | −0.52±0.55 | −0.10±0.57* | 0.05±0.65* | |
| Weight z score for BA | 0.56±0.57 | 0.64±0.56 | 1.18±0.59* | 1.19±0.62* | |
| BMI z score for BA | 1.10±0.43 | 1.13±0.48 | 1.44±0.55* | 1.36±0.54* | |
| Waist-to-height ratio | 0.520±0.034 | 0.530±0.030 | 0.535±0.043* | 0.530±0.042 |
Values are presented as mean±standard deviation.
CA, chronological age; BA, bone age; BMI, body mass index; GnRH, gonadotropin-releasing hormone.
Visit 1, at the start of treatment with GnRH agonist; visit 2, at 1 year after GnRH agonist treatment; visit 3, at the end of treatment with GnRH agonist; visit 4, at 6–12 months after GnRH agonist discontinuation
*P<0.05, compared to the values at visit 1.