Figure 3.

Autonomic output rhythms were improved by the TRF regimen. The autonomic outputs from ad lib (black circles) and TRF (orange triangles) Q175 mice were recorded simultaneously using telemetry device. A–D, Hourly running averages of activity (A), CBT (B), HR (C), and HRV from both groups are plotted (D). E, The HR rhythm amplitude, determined by the ratio of max and min of the day, in control and TRF-treated Q175 mice. F, The 24-h averaged HRV in control and TRF-treated Q175 mice. The temporal waveforms of autonomic outputs were analyzed using a two-way RM ANOVA with time and treatment as factors. Other comparisons between Q175 cohorts were made using a t test. Asterisks represent significant differences due to TRF regimen compared to ad lib controls (p < 0.05); n = 7/group.