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. 2017 Dec 1;7(12):2395–2405.

Figure 3.

Figure 3

Tigecycline significantly enhances the standard chemotherapeutic drugs in vitro efficacy in ALL cells. Combination of tigecycline (5 µM) with doxorubicin (5 nM) or vincristine (10 nM) inhibits more proliferation (A) and induces more apoptosis (B) in ALL cell lines than doxorubicin or vincristine alone. Combination of tigecycline (5 µM) with doxorubicin (10 nM) or vincristine (20 nM) induces more apoptosis (C) and inhibits more colony formation (D) in ALL CD34 cells or lymphoma cells than doxorubicin or vincristine alone. Combination of tigecycline with doxorubicin or vincristine has minimal effects on normal CD34 or lymphoma cells. Tig, tigecycline; Vin, vincristine; Dox, doxorubicin. *P<0.05, compared to single drug alone.