Table 2.
Univariate and multivariate analyses of factors associated with overall survival and recurrence in 393 patients with hepatocellular carcinoma
| Factors | OS | Cumulative recurrence | ||||||
|---|---|---|---|---|---|---|---|---|
|
|
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| Univariate | Multivariate | Univariate | Multivariate | |||||
|
|
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| P-value | HR | 95% CI | P-value | P-value | HR | 95% CI | P-value | |
| Sex (female vs. male) | 0.205 | NA | 0.435 | NA | ||||
| Age, years (≤ 50 vs. > 50) | 0.868 | NA | 0.782 | NA | ||||
| HBsAg (positive vs. negative) | 0.216 | NA | 0.155 | NA | ||||
| HCVAb (positive vs. negative) | 0.820 | NA | 0.922 | NA | ||||
| Liver cirrhosis (yes vs. no) | 0.009* | 1.513 | 1.061-2.159 | 0.022* | 0.002* | 1.587 | 1.139-2.211 | 0.006* |
| Serum AFP, ng/mL (≤ 20 vs. > 20) | 0.011* | 1.347 | 1.028-1.765 | 0.031* | 0.061 | NA | ||
| Serum ALT, U/L (≤ 75 vs. > 75) | 0.855 | NA | 0.585 | NA | ||||
| Tumor size (diameter, cm) (> 5 vs. ≤ 5) | 0.031* | NS | 0.373 | NA | ||||
| Tumor encapsulation (absent vs. present) | 0.017* | NS | 0.074 | NA | ||||
| Microvascular invasion (yes vs. no) | < 0.001* | 1.351 | 1.011-1.805 | 0.042* | 0.001* | 1.356 | 1.037-1.773 | 0.026* |
| Tumor number (multiple vs. single) | < 0.001* | 1.785 | 1.322-2.412 | < 0.001* | < 0.001* | 1.831 | 1.381-2.427 | < 0.001* |
| Tumor differentiation (III/IV vs. I/II) | 0.316 | NA | 0.336 | NA | ||||
| SLC29A1 expression (high vs. low) | 0.026* | 0.691 | 0.535-0.894 | 0.005* | 0.003* | 0.677 | 0.534-0.860 | 0.001* |
Abbreviations and Notes: OS, overall survival; NA, not adopted; NS, not significant; AFP, alpha-fetoprotein; ALT, alanine aminotransferase; HBsAg, hepatitis B surface antigen; 95% CI, 95% confidence interval; HR, hazard ratio; Cox proportional hazards regression model.
*
P-values < 0.05 were considered statistically significant.