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. 2017 Dec 28;23(48):8452–8464. doi: 10.3748/wjg.v23.i48.8452

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©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.

This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.

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The intestinal barrier is restored after 30 min of ischema followed by 120 min of reperfusion. A: At 120 min of reperfusion (30I120R) the epithelial lining appeared histologically intact compared to control tissue with ZO-1, occludin and E-Cadherin normally distributed across the villi.); B: In addition, electron microscopy revealed that lanthanum was no longer present in the paracellular spaces, indicating restored tight junction integrity; C: Moreover, the observed restoration of the intestinal barrier seems to correlate with permeability with the plasma L/R ratio normalized to 0.17 ± 0.06 which was no longer significantly different from control; D: Plasma I-FABP levels, reflecting intestinal epithelial damage, also returned to 14.77 ng/mL ± 5.46 ng/mL and were no longer significantly elevated compared to control. Electron microscopy scale bars = 0.5 μm and 2 μm respectively.