Table 1.
Assessment of colon lesions in rats subjected to obstruction of the left colic artery and vein by two ligations for 15 min (pale flat areas without mucosal folds as a percentage of the area of the blood-deprived colon segment; mean ± SD)
| Medication (/kg, 1-ml bath/rat) at the 25-mm blood-flow-deprived colon segment | Pale areas without mucosal folds as a percentage of the area of the blood-deprived colon segment, mean ± SD |
| 0.9% NaCl (control) | 46 ± 8 |
| BPC 157 (10 µg) | 7 ± 2a |
| L-NAME (5 mg) | 80 ± 10a |
| L-arginine (100 mg) | 65 ± 6a |
| L-NAME (5 mg) + L-arginine (100 mg) | 50 ± 8 |
| L-NAME (5 mg) + BPC 157 (10 µg) | 10 ± 4a |
| L-arginine (100 mg) + BPC 157 (10 µg) | 6 ± 2a |
| L-NAME (5 mg) + L-arginine (100 mg) + BPC 157 (10 µg) | 8 ± 2a |
The following medications or treatments (/kg, 1-mL bath/rat) were applied to the 25-mm blood-flow-deprived colon segment at 1 min post-injury: BPC 157 (10 µg); the NOS blocker L-NAME (5 mg) and the NOS substrate L-arginine (100 mg), alone or combined; equal volume of saline bath (controls).
a
P < 0.05 at least vs control.