Table 4.
Genotypic and allelic distributions of the investigated polymorphisms for patients with colorectal cancer in comparison to control group
| Genotype | CRC | Control | P value1 | OR (95%CI)a | Genotype | CRC | Control | P-value1 | OR (95%CI)1 |
| CASP8 | 63 | 475 | RP2/RP2 | 16 (25.4) | 154 (32.5) | 0.871 | 1.068 (0.482-2.368) | ||
| DEL/DEL | 13 (20.6) | 90 (19.0) | 0.676 | 0.888 (0.508-1.552) | Allele RP1 | 0.44 | 0.41 | ||
| INS/DEL | 28 (44.4) | 230 (48.4) | Allele RP2 | 0.56 | 0.59 | ||||
| INS/INS | 22 (35.0) | 155 (32.6) | 0.939 | 0.974 (0.503-1.887) | NFKB1 | 63 | 473 | ||
| Allele DEL | 0.43 | 0.43 | DEL/DEL | 16 (25.4) | 117 (24.7) | 0.0062 | 3.732 (1.451-9.599) | ||
| Allele INS | 0.57 | 0.57 | INS/DEL | 42 (66.7) | 246 (52.0) | ||||
| MDM2 | 64 | 475 | INS/INS | 5 (7.9) | 110 (23.3) | 0.829 | 0.935 (0.508-1.723) | ||
| DEL/DEL | 7 (10.9) | 33 (6.9) | 0.412 | 1.166 (0.143-9.487) | Allele DEL | 0.60 | 0.51 | ||
| INS/DEL | 25 (39.1) | 168 (35.4) | Allele INS | 0.40 | 0.49 | ||||
| INS/INS | 32 (50.0) | 274 (57.7) | 0.986 | 0.995 (0.546-1.811) | PAR1 | 63 | 473 | ||
| Allele DEL | 0.30 | 0.25 | DEL/DEL | 37 (58.7) | 273 (57.7) | 0.464 | 0.704 (0.275-1.801) | ||
| Allele INS | 0.70 | 0.75 | INS/DEL | 20 (31.8) | 169 (35.7) | ||||
| TP53 | 64 | 475 | INS/INS | 6 (9.5) | 31 (6.6) | 0.813 | 0.937 (0.546-1.608) | ||
| DEL/DEL | 47 (73.4) | 350 (73.7) | 0.886 | 1.166 (0.143-9.487) | Allele DEL | 0.75 | 0.76 | ||
| INS/DEL | 16 (25.0) | 116 (24.4) | Allele INS | 0.25 | 0.24 | ||||
| INS/INS | 1 (1.6) | 9 (1.9) | 0.986 | 0.995 (0.546-1.811) | CYP2E1 | 62 | 475 | ||
| Allele DEL | 0.86 | 0.86 | DEL/DEL | 56 (90.3) | 398 (83.8) | 0.999 | 189364591.0 (0.000) | ||
| Allele INS | 0.14 | 0.14 | INS/DEL | 6 (9.7) | 73 (15.4) | ||||
| TYMS | 63 | 475 | INS/INS | 0 (0.0) | 4 (0.8) | 0.351 | 0.655 (0.269-1.593) | ||
| DEL/DEL | 11 (17.5) | 65 (13.7) | 0.304 | 1.342 (0.765-2.354) | Allele DEL | 0.95 | 0.91 | ||
| INS/DEL | 31 (49.2) | 224 (47.2) | Allele INS | 0.05 | 0.09 | ||||
| INS/INS | 21 (33.3) | 186 (39.2) | 0.429 | 0.751 (0.369-1.526) | CYP19A1 | 64 | 475 | ||
| Allele DEL | 0.42 | 0.37 | DEL/DEL | 7 (10.9) | 76 (16.0) | 0.297 | 0.747 (0.431-1.293) | ||
| Allele INS | 0.58 | 0.63 | INS/DEL | 33 (51.6) | 248 (52.2) | ||||
| XRCC1 | 64 | 474 | INS/INS | 24 (37.5) | 151 (31.8) | 0.313 | 1.532 (0.669-3.508) | ||
| DEL/DEL | 4 (6.2) | 35 (7.4) | 0.771 | 1.082 (0.637-1.838) | Allele DEL | 0.37 | 0.42 | ||
| INS/DEL | 27 (42.2) | 179 (37.8) | Allele INS | 0.63 | 0.58 | ||||
| INS/INS | 33 (51.6) | 260 (54.8) | 0.445 | 1.528 (0.515-4.535) | UGT1A1 | 63 | 464 | ||
| Allele DEL | 0.27 | 0.26 | *1/*1 | 20 (31.7) | 206 (44.5) | 0.098 | 0.541 (0.262-1.120) | ||
| Allele INS | 0.73 | 0.74 | *1/*28 | 32 (50.8) | 209 (45.0) | ||||
| IL1A | 64 | 475 | *28/*28 | 6 (9.5) | 46 (9.9) | 0.370 | 1.282 (0.745-2.205) | ||
| DEL/DEL | 10 (15.6) | 86 (18.1) | 0.657 | 0.880 (0.500-1.548) | *36/*1 | 3 (4.8) | 3 (0.6) | ||
| INS/DEL | 33 (51.6) | 246 (51.8) | *36/*37 | 1 (1.6) | 0 (0.0) | 0.0012 | 12.849 (2.906-56.817) | ||
| INS/INS | 21 (32.8) | 143 (30.1) | 0.610 | 1.208 (0.584-2.368) | *1/*37 | 1 (1.6) | 0 (0.0) | ||
| Allele DEL | 0.41 | 0.44 | Allele *36 | 0.03 | 0.01 | ||||
| Allele INS | 0.59 | 0.56 | Allele *1 | 0.60 | 0.67 | ||||
| IL4 | 63 | 474 | Allele *28 | 0.35 | 0.32 | ||||
| RP1/RP1 | 8 (12.7) | 69 (14.5) | 0.195 | 1.493 (0.814-2.740) | Allele *37 | 0.02 | 0.00 | ||
| RP1/RP2 | 39 (61.9) | 251 (53.0) |
Data for CRC and Control columns are presented as n or n (%).
1
Analysis of combined genotypes (INS/INS vs others, or DEL/DEL vs others) with adjusted values for confounding factors (European and African ancestries) in logistic regression;
2
Statistically significant. CRC: Colorectal cancer; INDEL: Insertion/deletion.