Table 2. Hazard ratios of association between Lp-PLA2, lipid profile and other cardiac biochemistry parameters with the event of CAD after univariate Cox regression analysis.
| Variables | Hazards ratio | 95% CI | P value* |
|---|---|---|---|
| HDL-C, mg/dL | 0.99 | 0.96–1.02 | 0.64 |
| LDL-C, mg/dL | 0.99 | 0.98–1 | 0.29 |
| Lp(a), mg/dL | 0.99 | 0.98–1.01 | 0.51 |
| VLDL-C, mg/dL | 1.02 | 0.99–1.05 | 0.06 |
| ApoA1, mg/dL | 0.95 | 0.93–0.97 | <0.001 |
| ApoB, mg/dL | 0.99 | 0.98–1 | 0.25 |
| Non-HDL-C, mg/dL | 1 | 0.99–1 | 0.82 |
| Total cholesterol, mg/dL | 1 | 0.99-1.01 | 0.93 |
| Triglycerides, mg/dL | 1.01 | 1–1.01 | 0.06 |
| hs-CRP, mg/L | 1.08 | 1.01–1.16 | 0.03 |
| Lp-PLA2 conc†, ng/mL | 1.003 | 1.001–1.006 | 0.02 |
| Lp-PLA2 activity, nmol/min/mL | 0.995 | 0.99–1 | 0.27 |
| ApoB/ApoA1 ratio | 7.6 | 1.42–40 | 0.02 |
| TG/HDL-C ratio | 1.17 | 1.01–1.36 | 0.04 |
| TC/HDL-C ratio | 1.12 | 0.89–1.41 | 0.33 |
†, concentration also known as Lp-PLA2 mass; *, variables with P value <0.25 were selected for multivariable analysis reported in Table 3. Lp-PLA2, lipoprotein associated phospholipase A2; CAD, coronary artery disease; CI, confidence interval; LDL-C, low-density lipoprotein cholesterol; HDL-C, high-density lipoprotein cholesterol; VLDL-C, very low-density lipoprotein cholesterol; hs-CRP, high sensitivity C-reactive protein.