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. 2017 Oct 27;28(1):22–34. doi: 10.1038/cr.2017.134

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Copyright © 2017 The Author(s)

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Derivation of AFSCs and ASCs. (A) Schematic overview of AFSC derivation. Note AP-positive cells (arrow indicated) in AFSCs. Scale bars, 100 μm. (B) Derivation rate of AFSCs with diverse genetic backgrounds. (C) Quantitative RT-PCR of key genes in ESCs, EpiLCs, AFSCs and EpiSCs, all derived from 129/sv females mated with GOF-GFP males of mixed background. Note the expression of endoderm and mesoderm genes in AFSCs (at the bottom). (D) Reprogramming AFSC to ASCs. Scale bars, 100 μm.