Skip to main content
. 2017 Nov 10;28(1):69–89. doi: 10.1038/cr.2017.139

Figure 3.

Figure 3

Filia and Floped cooperatively regulate replication fork restart. (A) Rates of stalled replication fork restart in wild-type (WT), Filia-knockout (FK), FiliaS349A-rescued (FK-FiliaS349A) and WT Filia-rescued (FK-Filia) ESCs. (B) Rates of stalled fork restart in NIH3T3 cells with or without ectopic Filia expression. (C) Rates of stalled fork restart in WT, Floped-knockout (Floped-KO) and Floped-rescued ESCs. (D) Rates of stalled fork restart in NIH3T3 cells with or without ectopic expression of Floped. (E) Rates of fork restart in WT, Filia-knockout (Filia-KO), Floped-knockout (Floped-KO), and double deficient ESCs with or without HU treatment. (F) Rates of fork restart in NIH3T3 cells expressing Filia and/or Floped. Data are represented as mean ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001.