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Locations of different mutations in RML. (A) Distribution of three stabilizing residues (sticks) and functionally important regions of RML (residues within 5 Å of the catalytic triad are shown as cyan spheres). (B) Locations of two stabilizing disulfide bonds (sticks) and functionally important regions of RML (residues within 5 Å of the catalytic triad are shown as cyan spheres).
