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Role of DEX on the HMGB1 and RAGE levels in lung sample and BALF from WT rats with CLP-stimulated ALI. Rats were infused continuously with DEX or NS through the femoral vein cannula 30 min after CLP. A, B. BALF HMGB1 and sRAGE protein levels were measured by ELISA; C, D. Lung HMGB1 and RAGE protein levels were measured by Western Blot; E, F. Lung HMGB1 and RAGE mRNA expression were measured by Real-Time PCR. *P<0.05, #P<0.01 CLP vs. CLP+DEX. DEX, dexmedetomidine.
