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. 2017 Dec 15;9(12):5245–5258.

Figure 5.

Figure 5

Role of Anti-RAGE Ab on the levels of inflammatory molecules from WT rats with CLP-stimulated ALI. Rats were intraperitoneal administration with Anti-RAGE Ab (10 mg/kg) 1 h before CLP, and then the rats were administration with DEX (10 μg·kg-1· h-1, i.v.) or normal saline after CLP. BALF was harvested to measure the inflammatory molecules TNF-α (A), IL-1β (B), IL-6 (C), and HMGB1 (D). *P<0.05 CLP vs. CLP+DEX, #P<0.05 CLP+Anti-RAGE Ab/DEX vs. CLP+Anti-RAGE Ab+DEX, $P<0.05 CLP+Anti-RAGE Ab vs. CLP+DEX. DEX, dexmedetomidine.